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Update on Quantitative Imaging for Predicting and Assessing Response in Oncology.

Jennifer A Gillman¹, Austin R Pantel¹, David A Mankoff¹

¹Department of Radiology, Division of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Seminars in Nuclear Medicine

|October 16, 2020

Summary

Molecular imaging uses targeted radiotracers as biomarkers for cancer assessment and treatment tailoring. This review highlights applications in response evaluation and predicting long-term outcomes for various cancers.

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Area of Science:

Oncology
Molecular Imaging
Biomarkers

Background:

Molecular imaging enhances oncology by assessing cancer biology noninvasively.
Radiotracers serve as biomarkers for cancer characterization, prognosis, and treatment response.
Imaging biomarkers guide personalized therapeutic strategies based on tumor biology.

Purpose of the Study:

To review molecular imaging biomarker applications for cancer response assessment.
To explore the use of biomarkers in predicting long-term patient outcomes.
To discuss the role of molecular imaging in advancing precision medicine.

Main Methods:

Review of existing literature on molecular imaging biomarkers in oncology.
Discussion of specific radiotracers like 18F-fluorodeoxyglucose (FDG), 16α-18F-fluoro-17β-estradiol, and 18F-fluorothymidine.
Illustrative examples of biomarker applications in lymphoma, breast, and lung cancer.

Main Results:

18F-fluorodeoxyglucose (FDG) is a widely accepted biomarker for assessing cellular glucose metabolism in various cancers.
FDG is integrated into routine clinical care, particularly for lymphoma.
Novel tracers like 16α-18F-fluoro-17β-estradiol and 18F-fluorothymidine show promise for early breast cancer response prediction.

Conclusions:

Molecular imaging biomarkers are crucial for tailoring cancer therapies.
These biomarkers aid in evaluating treatment response and predicting survival.
Continued development and application of molecular imaging advance precision oncology.