Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

473
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
473
Ventilatory Modes01:14

Ventilatory Modes

912
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
912
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

2.0K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.0K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

396
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
396
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

2.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.5K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

837
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
837

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outflow Tract Patency and Ventricular Compression as Determinants of CPR Hemodynamics in a TEE-Guided Swine Model of Cardiac Arrest.

Anesthesiology·2026
Same author

Brown adipose-derived mesenchymal stromal cells improve sepsis-induced multiorgan dysfunction more than white adipose cells in obese rats.

Cytotherapy·2026
Same author

Tubular Damage Biomarkers Are a Useful Tool for Identifying Early Renal Injury in Long COVID.

International journal of molecular sciences·2026
Same author

Mitochondrial Transplantation from Bone Marrow Mesenchymal Stromal Cells Combined with Sildenafil Attenuated Vascular Remodeling and Improved Right Ventricular Dysfunction in Experimental Pulmonary Arterial Hypertension.

International journal of molecular sciences·2026
Same author

Glial Cells as Central Players in Neuroinflammation and Neuronal Damage Caused by Bacterial Pneumonia.

Neuroimmunomodulation·2026
Same author

Mechanical Power and Driving Pressure: Mechanisms of Lung Injury, Markers of Pathophysiology, or Therapeutic Targets?

Journal of clinical medicine·2026

Related Experiment Video

Updated: Dec 5, 2025

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.1K

Time-Controlled Adaptive Ventilation Versus Volume-Controlled Ventilation in Experimental Pneumonia.

Raquel F de Magalhães1, Daniela G Cruz1, Mariana A Antunes1

  • 1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Critical Care Medicine
|October 16, 2020
PubMed
Summary

Time-controlled adaptive ventilation stabilized alveoli, reducing lung damage and inflammation in a pneumonia model. This strategy showed improved epithelial cell integrity and lower bacteremia compared to volume-controlled ventilation.

More Related Videos

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

28.3K
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
07:55

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Published on: May 5, 2011

18.8K

Related Experiment Videos

Last Updated: Dec 5, 2025

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.1K
Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

28.3K
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
07:55

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Published on: May 5, 2011

18.8K

Area of Science:

  • Respiratory physiology
  • Critical care medicine
  • Pulmonary inflammation

Background:

  • Alveolar instability is a key issue in pneumonia, potentially exacerbated by mechanical ventilation.
  • Volume-controlled ventilation (VCV) may lead to lung injury.
  • Time-controlled adaptive ventilation (TCAV) aims to improve alveolar stability by controlling inspiratory and expiratory durations.

Purpose of the Study:

  • To investigate the effects of TCAV on lung injury and inflammation in a Pseudomonas aeruginosa-induced pneumonia model.
  • To compare TCAV with VCV at similar levels of mean airway pressure and positive end-expiratory pressure (PEEP).

Main Methods:

  • Wistar rats with induced pneumonia were ventilated using either TCAV or VCV for 1 hour.
  • TCAV involved specific settings for tidal volume, inspiratory/expiratory durations, and release pressure.
  • VCV was adjusted to match TCAV's mean airway pressure and PEEP.
  • Lung tissue was analyzed for heterogeneity, inflammatory biomarkers (IL-6, CINC-1), and epithelial integrity (E-cadherin).
  • Bacteremia and bacterial load were also assessed.

Main Results:

  • TCAV significantly reduced lung heterogeneity and expression of pro-inflammatory biomarkers (IL-6, CINC-1) compared to VCV.
  • Epithelial cell integrity, indicated by E-cadherin expression, was higher with TCAV.
  • Animals ventilated with TCAV exhibited lower bacteremia counts.
  • Lung edema and CINC-1 gene expression were more reduced with TCAV compared to VCV.

Conclusions:

  • In this pneumonia model, TCAV demonstrated reduced lung damage and inflammation compared to VCV when applied at similar tidal volumes and mean airway pressures.
  • TCAV may offer a protective ventilatory strategy by improving alveolar stability and mitigating ventilator-induced lung injury.