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Correlation between aortic root dimension and coronary ectasia

Gabriele Ghetti1, Nevio Taglieri, Francesco Donati

  • 1Department of Cardiology, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.

Coronary Artery Disease
|October 16, 2020
PubMed

Insights

Aortic aneurysm severity correlates with coronary artery ectasia (CAE) extent. Larger ascending aorta diameters in patients with CAE indicate more widespread coronary ectasia, suggesting a shared pathophysiological link.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Radiology

Background:

  • Aortic aneurysms and coronary artery ectasia (CAE) are linked conditions.
  • The relationship between the extent of CAE and aortic dilatation severity is not well understood.
  • This study investigates the connection between angiographic CAE extension and aortic dimensions.

Purpose of the Study:

  • To determine the association between the severity of aortic dilatation and the extent of coronary artery ectasia.
  • To explore potential shared mechanisms in cardiovascular diseases.

Main Methods:

  • Retrospective analysis of 135 patients with angiographically diagnosed CAE.
  • Patients categorized into four groups based on ascending aorta diameter.
  • Multivariable linear regression used to assess the relationship between aortic dimension and total estimated ectatic area (EEA total).

Main Results:

  • Ascending aorta diameter and C-reactive protein (CRP) showed a linear association with total EEA on univariable analysis.
  • After adjusting for CRP, ascending aorta diameter remained significantly associated with the extent of CAE.
  • Patients with larger aortas (>55 mm) were more likely to have higher neutrophil counts and neutrophil-to-lymphocyte ratios.

Conclusions:

  • A significant linear association exists between aortic dimension and the extent of coronary artery ectasia in patients diagnosed with CAE.
  • Ascending aorta diameter is a key predictor of CAE extent.
Abstract

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