Related Experiment Video

Updated: Dec 5, 2025

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.5K

Additional roles of diastolic parameters in the diagnosis of obstructive coronary artery disease

Hyue Mee Kim1,2, Hack-Lyoung Kim1, Myung-A Kim1

  • 1Department of Internal Medicine, Division of Cardiology, Seoul National University College of Medicine, Seoul National University Boramae Medical Center.

Coronary Artery Disease
|October 16, 2020
PubMed

Insights

Septal e´ velocity, a key diastolic parameter, is strongly linked to obstructive coronary artery disease (CAD) in patients with normal ejection fraction. This measurement also enhances the diagnostic accuracy of the treadmill exercise test for detecting CAD.

Area of Science:

  • Cardiology
  • Echocardiography
  • Diabetology

Background:

  • Echocardiographic assessment of left ventricular diastolic dysfunction relies on four key indicators: annular e´ velocity, E/e´, left atrial size, and peak tricuspid regurgitation velocity.
  • Guidelines highlight these parameters for evaluating diastolic dysfunction.

Purpose of the Study:

  • To investigate the relationship between four diastolic parameters and obstructive coronary artery disease (CAD).
  • To determine if septal e´ velocity can improve the diagnostic accuracy of the treadmill exercise test (TET) for obstructive CAD.

Main Methods:

  • Utilized data from a nationwide registry of 1307 patients with normal left ventricular ejection fraction (LVEF) undergoing coronary angiography.
  • Assessed septal e´ velocity, E/e´, left atrial dimension (LAd), and tricuspid regurgitation velocity using transthoracic echocardiography.

Main Results:

  • Patients with obstructive CAD exhibited more advanced left ventricular diastolic dysfunction compared to those without.
  • Low septal e´ velocity (<7 cm/s) was identified as an independent risk factor for obstructive CAD (OR, 1.91; P=0.026).
  • Septal e´ velocity demonstrated superior performance in detecting obstructive CAD compared to other diastolic parameters and significantly improved the diagnostic value of the TET.

Conclusions:

  • Septal e´ velocity is the most potent among the four assessed diastolic parameters in its association with obstructive CAD in stable patients with normal LVEF.
  • Incorporating septal e´ velocity can enhance the diagnostic capabilities of the treadmill exercise test for identifying obstructive CAD.
Abstract

More Related Videos

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.4K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.6K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
117
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
209
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
289
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
117
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
240
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
147