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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

538
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
538
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

219
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
219
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

289
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
289
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

244
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
244
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

715
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
715
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

211
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
211

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Updated: Dec 5, 2025

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Current concepts in atherosclerosis.

Mohammad Alkhalil1,2, Robin P Choudhury1

  • 1Acute Vascular Imaging Centre, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU UK.

Indian Journal of Thoracic and Cardiovascular Surgery
|October 16, 2020
PubMed
Summary
This summary is machine-generated.

Atherosclerosis involves lipoprotein retention and inflammation, with perivascular adipose tissue emerging as a key factor. Novel therapies targeting lipids and inflammation show promise in reducing cardiovascular events.

Keywords:
AtherosclerosisInflammationLipids

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Area of Science:

  • Cardiovascular Science
  • Immunology
  • Metabolic Disease

Background:

  • Atherosclerosis is a complex disease driven by lipoprotein retention and inflammatory cells.
  • Low-density lipoprotein cholesterol (LDL-c) is a known cause, with monocytes and foam cells linked to disease progression.
  • Perivascular adipose tissue (PVAT) is increasingly recognized for its role in plaque inflammation.

Purpose of the Study:

  • To review the pathogenesis of atherosclerosis, incorporating novel insights.
  • To discuss current and emerging therapeutic strategies for atherosclerosis management.
  • To highlight the interplay between lipids, inflammation, and PVAT in atherosclerosis.

Main Methods:

  • Literature review of atherosclerosis pathogenesis.
  • Analysis of emerging data on PVAT and inflammation.
  • Evaluation of novel anti-atherosclerotic therapies.

Main Results:

  • Lipoprotein retention and inflammation are central to atherosclerosis.
  • PVAT influences atherosclerotic plaque inflammatory status.
  • Novel therapies like PCSK-9 inhibitors and IL-1ß antibodies demonstrate efficacy.

Conclusions:

  • Understanding atherosclerosis requires integrating lipid, inflammatory, and novel factors like PVAT.
  • Targeting both lipid retention and inflammation is crucial for effective treatment.
  • Emerging therapies offer new hope for managing cardiovascular events in atherosclerosis patients.