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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

210
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
210
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

169
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
169
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

240
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
240
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

145
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
145
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

272
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
272
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

259
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
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Related Experiment Video

Updated: Dec 5, 2025

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Aortic root surgery in Marfan syndrome.

Shiv Kumar Choudhary1, Aayush Goyal1

  • 1The Department of Cardiothoracic & Vascular Surgery, All India Institute of Medical Science, New Delhi, 110029 India.

Indian Journal of Thoracic and Cardiovascular Surgery
|October 16, 2020
PubMed
Summary

Marfan syndrome (MFS), caused by FBN-1 gene mutations, leads to aortic complications. Surgical aortic root replacement significantly improves survival, with choices like TRR and VSRR offering good outcomes.

Keywords:
Aortic root aneurysmAortic root surgeryMarfan syndrome

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Area of Science:

  • Cardiovascular Surgery
  • Genetics
  • Connective Tissue Diseases

Background:

  • Marfan syndrome (MFS) is an inherited connective tissue disorder.
  • FBN-1 gene mutations disrupt microfibril structure, leading to aortic root dilatation, aneurysms, and dissections.
  • These aortic complications are the primary cause of reduced life expectancy in MFS patients.

Purpose of the Study:

  • To review surgical options for aortic root complications in Marfan syndrome.
  • To compare the outcomes of different aortic root replacement techniques.
  • To discuss emerging alternative treatments and long-term management.

Main Methods:

  • Review of current surgical techniques for aortic root replacement in MFS.
  • Comparison of total root replacement (TRR) and valve-sparing root replacement (VSRR) outcomes.
  • Evaluation of personalized external aortic root support (PEARS) as an alternative.

Main Results:

  • Both TRR and VSRR provide excellent early and late results for MFS patients.
  • TRR offers improved long-term survival and event-free survival due to low prosthetic valve risks.
  • VSRR is a viable option for 10-15 years post-surgery; PEARS is a promising alternative.

Conclusions:

  • Surgical intervention, including TRR and VSRR, significantly improves survival in MFS patients.
  • Procedure choice depends on patient-specific factors, surgeon expertise, and aortic morphology.
  • Lifelong monitoring is essential for all MFS patients post-surgery.