Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PAHs formation and distribution: Mechanistic insights from pyrolysis of chlorine-rich waste polyvinyl dichloride.

Journal of hazardous materials·2026
Same author

Circulating CCDC3 as an Indicator of Visceral Fat Accumulation in Patients with Type 2 Diabetes Mellitus.

Metabolites·2026
Same author

DUSP11 is an Intracellular Innate Immune Checkpoint in Lung Adenocarcinoma.

Cancer immunology research·2025
Same author

Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine.

Mechanobiology in medicine·2025
Same author

Whole-body vibration protects against chronic high-altitude hypoxic bone loss by regulating the nitric oxide/HIF-1α axis in osteoblasts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

Structure, ingredient, and function-based biomimetic scaffolds for accelerated healing of tendon-bone interface.

Journal of orthopaedic translation·2024

Related Experiment Video

Updated: Dec 5, 2025

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG hOMING
07:36

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG hOMING

Published on: March 14, 2019

7.3K

Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets.

Xue Bai1,2, Qilin Pei3, Chunyi Pu1,2

  • 1Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, People's Republic of China.

Drug Design, Development and Therapy
|October 16, 2020
PubMed
Summary

This study proposes a novel hydrogel to protect pancreatic islet grafts for type 1 diabetes (T1D) treatment. The functionalized hydrogel aims to improve islet survival and function post-transplantation by preventing rejection and hypoxia.

Keywords:
T1Dbiomaterialsencapsulationhydrogelislet transplantation

More Related Videos

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

10.6K
Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue
06:39

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue

Published on: May 25, 2021

2.3K

Related Experiment Videos

Last Updated: Dec 5, 2025

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG hOMING
07:36

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG hOMING

Published on: March 14, 2019

7.3K
Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

10.6K
Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue
06:39

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue

Published on: May 25, 2021

2.3K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Immunology

Background:

  • Islet transplantation is a leading treatment for type 1 diabetes (T1D).
  • Grafted islet function declines due to transplant rejection and hypoxia.
  • Current strategies often combine only one or two protective methods.

Purpose of the Study:

  • To propose a hypothetical, multifunctional hydrogel encapsulation system for pancreatic islet transplantation.
  • To enhance the long-term survival and function of islet grafts.
  • To address limitations of existing T1D treatment approaches.

Main Methods:

  • Design of a functionalized hydrogel encapsulating A20 high-expressing islets and supporting cells.
  • Incorporation of natural biomaterials (e.g., heparin) for islet adhesion and survival.
  • Development as a drug delivery system for immunosuppressants and growth factors.
  • Inclusion of supporting cells to promote vascularization and immune protection.

Main Results:

  • The hydrogel provides mechanical support and gels in vivo.
  • Natural biomaterials enhance islet survival.
  • Encapsulated supporting cells aid vascularization and immune evasion.
  • Hypothesized improved long-term survival and function of islet grafts compared to naked islets.

Conclusions:

  • A multifunctional hydrogel offers a promising hypothetical approach to improve pancreatic islet transplantation outcomes for T1D.
  • This model integrates multiple protective strategies within a single system.
  • Further in vitro and in vivo studies are required to validate its clinical applicability and safety.