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The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes

Setila Dalili1, Shahin Koohmanaee1, Seyyed Amir Reza Nemati1

  • 1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|October 16, 2020
PubMed

Insights

This study found no significant link between serum inorganic phosphate and hemoglobin A1c (HbA1c) in children with type 1 diabetes. However, HbA1c showed an inverse relationship with body mass index (BMI) in pediatric diabetes patients.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Diseases
  • Biochemistry

Background:

  • Diabetes mellitus significantly alters cellular metabolism in children and adolescents.
  • Inorganic phosphate (Pi) imbalance is an early, unrecognized complication of diabetes, potentially causing hypoxia.
  • Clinical symptoms for high/low blood sugar are apparent, unlike plasma inorganic phosphate levels.

Purpose of the Study:

  • To investigate the association between hemoglobin A1c (HbA1c) and serum inorganic phosphate in pediatric patients with type 1 diabetes.
  • To understand the role of phosphate metabolism in pediatric diabetes management.
  • To identify potential unrecognized metabolic derangements in type 1 diabetes.

Main Methods:

  • Cross-sectional study of 102 children with type 1 diabetes.
  • Collected data on age, sex, BMI, diabetes duration, HbA1c, and serum phosphate.
  • Age-adjusted HbA1c levels were used in the final analysis.

Main Results:

  • A significant inverse correlation was observed between HbA1c and BMI (r=-0.215, P=0.03).
  • No significant correlation was found between HbA1c and serum phosphate levels.
  • No association was detected between HbA1c and age, height, weight, diabetes duration, or insulin dose.

Conclusions:

  • Serum inorganic phosphate levels are not correlated with HbA1c in children with type 1 diabetes.
  • HbA1c shows an inverse relationship with BMI in this pediatric cohort.
  • Further research is needed to understand phosphate dysregulation in pediatric diabetes.
Abstract

Keywords:
Iranchilddiabetes mellitusglycated hemoglobin Aphosphate

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