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Progress: Targeted Therapy, Immunotherapy, and New Chemotherapy Strategies in Advanced Triple-Negative Breast Cancer

Jinhong Shi1, Feiqi Liu1, Yanqiu Song1

  • 1Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Cancer Management and Research
|October 16, 2020
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive, lacking hormone receptors and HER2. Recent advances offer new targeted therapy, immunotherapy, and chemotherapy options for advanced TNBC.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype, representing ~15% of cases.
  • TNBC is characterized by the absence of estrogen receptors, progesterone receptors, and HER2 amplification.
  • Current treatments for advanced TNBC often rely on conventional chemotherapy with limited efficacy and poor prognosis.

Purpose of the Study:

  • To review recent advancements in therapeutic strategies for advanced triple-negative breast cancer.
  • To summarize progress in targeted therapy, immunotherapy, and chemotherapy for TNBC.

Main Methods:

  • Literature review of recent clinical trials and molecular studies.
  • Analysis of emerging treatment modalities for advanced TNBC.

Main Results:

  • Targeted therapies for signaling pathways show promise.
  • Immunotherapy targeting immune checkpoints offers new avenues.
  • Novel chemotherapy strategies are being developed.

Conclusions:

  • Advanced TNBC treatment is evolving with new therapeutic options.
  • Targeted therapy and immunotherapy represent significant progress.
  • Further research is crucial for improving outcomes in advanced TNBC.
Keywords:
advanced TNBCimmune checkpoint inhibitorrefractorytargets

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