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Whatever happened to multiple complex developmental disorder?

Annio Posar1,2, Paola Visconti1

  • 1IRCCS Institute of Neurological Sciences of Bologna, Child Neurology and Psychiatry Unit, Bologna, Italy.

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Summary

Multiple complex developmental disorder (MCDD) presents early-onset challenges in emotional regulation, social behavior, and thought processes. Recognizing MCDD is crucial as it may bridge autism and childhood-onset schizophrenia, though its distinct nature requires further research.

Keywords:
Autism spectrum disorderchildhoodmultiple complex developmental disorderpsychosisschizophrenia

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Area of Science:

  • Child and Adolescent Psychiatry
  • Developmental Neuroscience
  • Clinical Psychology

Background:

  • Multiple complex developmental disorder (MCDD) is characterized by early-onset impairments in affective regulation, social behavior, and thought processes.
  • MCDD has not achieved recognition as an autonomous nosographic entity in international classifications.
  • Historically, patients were often diagnosed with 'pervasive developmental disorder not otherwise specified'.

Purpose of the Study:

  • To review current literature on Multiple Complex Developmental Disorder (MCDD).
  • To explore the potential nosographic autonomy of MCDD.
  • To highlight the importance of recognizing MCDD due to its association with schizophrenia spectrum disorders.

Main Methods:

  • Literature review of clinical and neurobiological findings related to MCDD.
  • Analysis of diagnostic trends and historical classifications.
  • Exploration of the potential relationship between MCDD, autism spectrum disorder, and childhood-onset schizophrenia.

Main Results:

  • Despite declining interest, emerging findings suggest clinical and neurobiological support for MCDD's nosographic autonomy.
  • Children with MCDD show predisposition to developing schizophrenia spectrum disorders.
  • MCDD may represent a transitional condition between autism spectrum disorder and childhood-onset schizophrenia.

Conclusions:

  • Further research is needed to establish the recurrence, neurobiological underpinnings, and clinical course of MCDD.
  • Accurate recognition of MCDD is critical for understanding developmental trajectories and potential interventions.
  • MCDD warrants further investigation as a distinct clinical entity with significant implications for child mental health.