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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response

Cui Jiang1,2, Jingwei Liu1, Min Guo1

  • 1Institute of Translational Medicine, Key Laboratory of Cell Biology of Ministry of Public Health, and Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis, Treatment and Prevention, China Medical University, No. 77, Puhe Road, Shenyang North New Area, Shenyang, 110042, Liaoning, China.

International Journal of Biological Sciences
|October 16, 2020
PubMed

Insights

Sirtuin 2 (SIRT2) expression is lower in breast cancer patients' T cells, correlating with fewer CD8+ effector memory T (TEM) cells. This suggests SIRT2 plays a role in regulating T cell differentiation and the anti-tumor immune response.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase involved in various cellular processes.
  • The function of SIRT2 in cancer immunity is not well understood.
  • SIRT2 regulates mitosis, genomic integrity, cell homeostasis, and tumorigenesis.

Purpose of the Study:

  • To investigate the role of SIRT2 in the immune response to breast cancer.
  • To determine the correlation between SIRT2 expression and T cell populations in breast cancer patients.

Main Methods:

  • Analysis of SIRT2 expression in peripheral T lymphocytes from breast cancer patients and healthy individuals.
  • Correlation analysis between SIRT2 levels and CD8+ effector memory T (TEM) cell counts.
  • Examination of T cell differentiation in Sirt2-deficient mice.

Main Results:

  • SIRT2 expression was significantly lower in T lymphocytes of breast cancer patients compared to controls.
  • SIRT2 levels positively correlated with CD8+ TEM cells in breast cancer patients.
  • Sirt2 deficiency in mice led to decreased TEM cells and increased naive T cells, indicating altered T cell differentiation.
  • SIRT2 may upregulate CD8+ TEM cells by activating aerobic oxidation and inhibiting GSK3β acetylation.

Conclusions:

  • SIRT2 plays a role in regulating T cell differentiation.
  • SIRT2 influences the anti-tumor immune response.
  • SIRT2 may offer novel insights for cancer prevention and immunotherapy.
Keywords:
SIRT2T cellbreast cancerdifferentiation

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