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Anti-Tuberculosis Treatment: Induced Hepatotoxicity - A Case Report

Poludasari Shravan Kumar1, Rachakonda Vidya1, Tabassum1

  • 1Department of Pharmacy Practice, Malla Reddy Pharmacy College, Dhulapally, Secunderabad, Telangana, India.

EJIFCC
|October 16, 2020
PubMed

Insights

Tuberculosis treatment can cause liver damage (hepatotoxicity), a serious adverse drug reaction. This case highlights successful management of drug-induced liver injury in a young patient undergoing tuberculosis therapy.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Tuberculosis (TB) is a significant global health challenge, particularly in India.
  • Anti-tubercular drugs, while effective, are associated with adverse drug reactions (ADRs), notably hepatotoxicity.
  • Hepatotoxicity can manifest with symptoms like jaundice and vomiting, increasing mortality and reducing treatment efficacy.

Observation:

  • A 19-year-old female presented with jaundice and vomiting.
  • She had a history of tuberculosis treated with a Directly Observed Therapy (DOT) regimen.
  • Clinical presentation and investigations indicated Anti-Tuberculosis Treatment (ATT)-induced hepatotoxicity.

Findings:

  • The patient's symptoms were directly linked to the anti-tubercular medications.
  • Diagnosis was confirmed through clinical examination and laboratory results.
  • No specific antidote was required; management focused on supportive and symptomatic treatment.

Implications:

  • Early recognition and diagnosis of ATT-induced hepatotoxicity are crucial for patient outcomes.
  • Supportive and symptomatic management can effectively treat this ADR.
  • This case underscores the importance of monitoring liver function during tuberculosis treatment.
Keywords:
adverse drug reactiondirect observation therapyhepatotoxicitypulmonary tuberculosis

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