Implication of Gut Microbiota in Cardiovascular Diseases

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Wenyi Zhou1,2, Yiyu Cheng1, Ping Zhu2

  • 1Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.

Oxidative Medicine and Cellular Longevity
|October 16, 2020
PubMed

Insights

The gut microbiome influences cardiovascular diseases (CVDs) through metabolites and programmed cell death. Understanding this link may lead to new microbiota-targeted therapies for heart conditions.

Area of Science:

  • Microbiology
  • Cardiology
  • Immunology

Background:

  • Gut microbiota alterations are linked to cardiovascular diseases (CVDs).
  • Microbial metabolites like TMAO, SCFAs, and BAs play roles in CVD development and prognosis.
  • Programmed cell death pathways are emerging as crucial in microbiome-host interactions.

Purpose of the Study:

  • To review the relationship between gut microbiota and cardiac disorders.
  • To highlight the role of programmed cell death in this association.
  • To explore microbiota-targeted therapeutic strategies for CVD management.

Main Methods:

  • Literature review of recent studies.
  • Summary of findings on gut microbiota and cardiac disorders.
  • Focus on programmed cell death mechanisms.

Main Results:

  • Gut microbiota composition is altered in various CVDs.
  • Metabolites and programmed cell death are key mediators between gut microbes and heart health.
  • Specific programmed cell death types (apoptosis, pyroptosis, ferroptosis) are implicated.

Conclusions:

  • Gut microbiota significantly impacts cardiovascular health.
  • Programmed cell death is a critical pathway in the gut-heart axis.
  • Targeting the gut microbiome offers potential therapeutic avenues for CVDs.

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