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Candida auris in the Age of Resistance

Michael Oh1, Jonathan Heyl2, Benson A Babu3

  • 1Medicine, Lake Erie College of Osteopathic Medicine, Auburndale, USA.

Cureus
|October 16, 2020
PubMed

Insights

Candida auris is a multidrug-resistant fungus and a major public health threat. This overview details the factors contributing to its pathogenicity and spread.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health Microbiology

Background:

  • Candida auris is an emerging opportunistic yeast pathogen.
  • It has demonstrated multidrug resistance, posing a significant clinical challenge.
  • Designated a serious public health threat by the CDC, it is a growing concern in the United States.

Purpose of the Study:

  • To provide a comprehensive overview of Candida auris.
  • To elucidate the contributing factors to its pathogenicity.
  • To highlight its emergence as a multidrug-resistant pathogen.

Main Methods:

  • Literature review of C. auris research.
  • Analysis of epidemiological data on C. auris outbreaks.
  • Synthesis of information on virulence factors and resistance mechanisms.

Main Results:

  • C. auris exhibits remarkable adaptability and resistance to antifungal agents.
  • It can cause invasive infections with high mortality rates.
  • Environmental persistence and transmission in healthcare settings are key concerns.

Conclusions:

  • Understanding C. auris pathogenicity is crucial for effective control.
  • Multidrug resistance necessitates novel therapeutic and preventative strategies.
  • Continued surveillance and research are vital to combat this public health threat.
Keywords:
candida auris

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