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Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033)
Mary Barbara1,2, Sadhna Dhingra3, Ayse L Mindikoglu1,2
1Margaret M. and Albert B. Alkek Department of Medicine, Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX.
ACG Case Reports Journal
|October 16, 2020
Summary
Selective androgen receptor modulators (SARMs) like RAD-140 and LGD-4033 can cause drug-induced liver injury. A patient recovered after discontinuing these supplements, highlighting potential liver risks.
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Selective androgen receptor modulators (SARMs) are performance-enhancing compounds with potential therapeutic applications.
- RAD-140 and LGD-4033 are commonly found in unregulated supplements, raising safety concerns.
- Drug-induced liver injury (DILI) is a significant clinical concern, necessitating identification of causative agents.
Observation:
- A 52-year-old male presented with symptoms indicative of liver injury.
- The patient reported recent use of Alpha Bolic (containing RAD-140) and Alpha Elite (containing RAD-140 and LGD-4033) supplements.
- Liver biopsy revealed centrilobular cholestasis, ductular reaction, and granuloma formation, consistent with DILI.
Findings:
- Histopathological findings strongly suggested drug-induced liver injury.
- Elevated liver enzymes normalized approximately three months post-cessation of RAD-140 and LGD-4033 supplements.
- The study implicates RAD-140 and LGD-4033 as potential causes of hepatotoxicity.
Implications:
- This case highlights the potential hepatotoxicity associated with SARMs, particularly RAD-140 and LGD-4033.
- Healthcare providers should be aware of SARMs in supplements and their potential to cause liver injury.
- Further research into the mechanisms and clinical management of SARM-induced liver injury is warranted.