Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

3.9K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the Relationship Human Parvovirus B19 Infection in Benign and Malignant Salivary Gland Tumors.

Journal of dentistry (Shiraz, Iran)·2026
Same author

Histologic and micro-computed tomography confirmation of cementogenesis over calcium-enriched mixture cement in a human permanent tooth.

Journal of dental sciences·2025
Same author

Rapidly Progressing Radicular Cyst in an Endodontically Treated Tooth: Diagnostic Challenges, Advanced Imaging, and Surgical Management.

Clinical case reports·2025
Same author

Myoepithelioma of the upper lip: A rare case report with a literature review of diagnostic approaches.

SAGE open medical case reports·2025
Same author

Extramedullary Plasmacytoma of the Oral Cavity: A Rare Case in the Buccal Mucosa.

Clinical case reports·2025
Same author

The effect of physical exercise on circulating neurotrophic factors in healthy aged subjects: A meta-analysis and meta-regression.

Experimental gerontology·2024

Related Experiment Video

Updated: Dec 5, 2025

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.1K

Mel-CAM Expression in Common Oral Carcinomas.

Nafise Shamloo1, Nasim Taghavi1, Samira Behrad2

  • 1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Dentistry (Shiraz, Iran)
|October 16, 2020
PubMed
Summary

Mel-CAM (CD146) expression differs between oral squamous cell carcinoma (OSCC) and mucoepidermoid carcinoma (MEC). CD146 correlates with prognostic factors in OSCC, suggesting its potential as a prognostic marker for OSCC, but not for differentiating high-grade MEC from OSCC.

Keywords:
Mel-CAMMucoepidermoid carcinomaOral squamous cell carcinomaSalivary glands

More Related Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.0K
CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells
12:14

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

Published on: June 2, 2022

2.9K

Related Experiment Videos

Last Updated: Dec 5, 2025

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.1K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.0K
CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells
12:14

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

Published on: June 2, 2022

2.9K

Area of Science:

  • Oral pathology
  • Cancer biology
  • Immunohistochemistry

Background:

  • Mel-CAM (CD146, MUC18) is a cell adhesion glycoprotein with diagnostic potential in pathology.
  • Its role in normal and tumoral tissues highlights its significance in understanding disease progression.

Purpose of the Study:

  • To assess Mel-CAM expression in oral squamous cell carcinoma (OSCC) and salivary gland mucoepidermoid carcinoma (MEC).
  • To evaluate Mel-CAM's utility in differentiating OSCC from high-grade MEC.

Main Methods:

  • Immunohistochemical staining for CD146 was performed on 19 MEC and 17 OSCC specimens.
  • Statistical analysis included Mann-Whitney, Spearman's correlation, and Kruskal-Wallis tests using SPSS software.

Main Results:

  • Mel-CAM was expressed in all MEC and 10 OSCC cases, with significant differences between the groups (p=0.035).
  • In OSCC, CD146 expression correlated significantly with invasion mode, tumor size, and histological grade.
  • No significant correlation was found between CD146 expression and histological grade in MEC or lymph node metastasis in either group.

Conclusions:

  • CD146 expression may serve as a prognostic predictor in OSCC due to its correlation with prognostic factors.
  • Mel-CAM is not suitable for differentiating high-grade MEC from OSCC.
  • Further research may explore the specific prognostic implications of CD146 in OSCC.