The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis

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Marek Samec1, Alena Liskova1, Lenka Koklesova1

  • 1Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.

Journal of Cancer Research and Clinical Oncology
|October 16, 2020
PubMed

Insights

Phytochemicals can modulate the immune system to fight cancer. This study explores how these plant compounds regulate immune responses, offering potential as an anticancer therapy.

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • The immune system plays a critical role in cancer eradication, but tumors develop evasion mechanisms.
  • Phytochemicals are known to modulate innate and adaptive immunity through various actions.
  • Understanding phytochemicals' immunomodulatory effects is key to cancer research.

Purpose of the Study:

  • To comprehensively review the immunomodulatory potential of phytochemicals in cancer.
  • To investigate the impact of phytochemicals on immune response regulation during cancer development, tolerance, and escape.
  • To explore the clinical application of phytochemicals in anticancer therapy.

Main Methods:

  • Literature review of existing studies on phytochemicals and cancer immunology.
  • Analysis of mechanisms by which phytochemicals influence immune cells and molecules.
  • Evaluation of evidence for phytochemicals in modulating immune responses in cancer contexts.

Main Results:

  • Phytochemicals stimulate and amplify immune cell activity and humoral immunity.
  • These compounds can impact immune tolerance and aid in overcoming immune escape.
  • Evidence suggests a direct association between phytochemicals and immune system modulation.

Conclusions:

  • Phytochemicals possess significant immunomodulatory potential relevant to cancer.
  • Their ability to regulate immune responses presents a promising avenue for anticancer strategies.
  • Clinical application of phytochemicals could offer a novel approach to cancer treatment.
Keywords:
CancerCytokinesImmunomodulationPhytochemicalsPreclinical and clinical research

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