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From COVID-19 to clot: the involvement of the complement system
Mohamed A Hendaus1,2, Fatima A Jomha3
1Department of Pediatrics, Sidra Medicine and Research Center, Doha, Qatar.
Journal of Biomolecular Structure & Dynamics
|October 16, 2020
Summary
The complement system plays a key role in COVID-19 (coronavirus disease) pathogenesis, inflammation, and thrombosis. Blocking the terminal complement pathway may offer effective treatments for COVID-19 patients with blood clots.
Area of Science:
- Immunology
- Pathophysiology
- Hematology
Background:
- The emergence of coronavirus disease (COVID-19) in late 2019 has been linked to coagulation profile abnormalities.
- Understanding the immune response and pathogenesis of COVID-19 is crucial for developing effective treatments.
Purpose of the Study:
- To discuss the role of the complement system in COVID-19-associated thrombo-genesis, inflammation, and tissue damage.
- To explore potential therapeutic targets within the complement pathway for COVID-19 treatment.
Main Methods:
- Review of current literature on COVID-19, coagulation, and the complement system.
- Discussion of existing thrombosis treatments and novel therapeutic strategies targeting the complement cascade.
Main Results:
- The complement system is implicated in the immune response to COVID-19, contributing to inflammation and thrombosis.
- Blocking the terminal complement pathway presents a promising therapeutic avenue for managing COVID-19-related clotting.
Conclusions:
- The complement system's role in COVID-19 pathogenesis warrants further investigation.
- Targeting the terminal complement pathway could be a vital strategy for treating thrombosis in COVID-19 patients, potentially improving outcomes and facilitating early discharge.
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