Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

494
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
494
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

548
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
548
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

799
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
799
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

479
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
479
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

646
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
646
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

558
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
558

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Care of Patients Receiving Abemaciclib: Results From Clinical Trials and a Healthcare Provider Survey.

Clinical journal of oncology nursing·2026
Same author

GRADE concept article: Evaluating risk of bias in a body of evidence from studies of environmental and other exposures.

Environment international·2026
Same author

What US Medical Students Need to Learn About Clinical Practice Guidelines: A Qualitative Study of US Students and a Global Subset of Guidelines Developers.

Journal of clinical epidemiology·2026
Same author

Integrating Planetary Health in Health Guidelines (GRADE Guidance 46).

Annals of internal medicine·2026
Same author

American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy.

Epilepsy currents·2026
Same author

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Related Experiment Video

Updated: Dec 5, 2025

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.5K

ONS Guidelines™ for Opioid-Induced and Non-Opioid-Related Cancer Constipation.

Barbara Rogers1, Pamela K Ginex2, Allison Anbari3

  • 1Fox Chase Cancer Center.

Oncology Nursing Forum
|October 16, 2020
PubMed
Summary

This guideline offers 13 recommendations for managing constipation in cancer patients, including opioid-induced and non-opioid-related cases. It emphasizes bowel regimens and lifestyle education as first-line treatments.

Keywords:
GRADEacupuncturecancerconstipationguidelineopioid-induced constipation

More Related Videos

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.4K
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
12:37

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS

Published on: September 11, 2012

47.7K

Related Experiment Videos

Last Updated: Dec 5, 2025

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.5K
Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.4K
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
12:37

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS

Published on: September 11, 2012

47.7K

Area of Science:

  • Oncology
  • Gastroenterology
  • Evidence-Based Practice

Background:

  • Constipation is a common and distressing symptom in cancer patients.
  • Management of cancer-related constipation, including opioid-induced constipation, requires clear clinical guidance.

Purpose of the Study:

  • To develop evidence-based recommendations for the treatment of constipation in patients with cancer.
  • To support clinicians and patients in making informed decisions regarding constipation management.

Main Methods:

  • An interprofessional panel prioritized clinical questions and patient outcomes.
  • Systematic literature reviews were conducted.
  • The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach was used to assess evidence and formulate recommendations.

Main Results:

  • Thirteen recommendations were developed for managing cancer-related constipation.
  • A bowel regimen with lifestyle education is conditionally recommended as first-line treatment.
  • Prophylactic bowel regimens are suggested for patients initiating opioids.

Conclusions:

  • Pharmaceutical interventions are recommended if initial bowel regimens fail.
  • Acupuncture and electroacupuncture are recommended for non-opioid-related constipation within clinical trials.
  • These guidelines provide a comprehensive framework for managing constipation in oncology settings.