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Updated: Dec 5, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
Published on: July 10, 2016
Branching morphogenesis - historical first evidences
Domenico Ribatti1, Diego Guidolin
1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari. domenico.ribatti@uniba.it.
Abstract:
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. It requires the coordinated interplay of multiple types of epithelial cells with the surrounding extracellular matrix. Cell migration, proliferation, and extracellular matrix dynamics have different roles in driving budding in different organs. This historical review article summarizes the first founding literature data concerning branching morphogenesis occurring in kidney, lung, vascular system, mammary glands and neurons.
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