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Use of therapeutic plasma exchange for pediatric neurological diseases

Tina S Ipe1, Erin K Meyer2,3, Kimberly W Sanford4

  • 1Department of Pathology and Laboratory Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Journal of Clinical Apheresis
|October 16, 2020
PubMed

Insights

Therapeutic plasma exchange (TPE) effectively treats pediatric neurological diseases. Advances in apheresis technology have expanded its use in children for various nervous system disorders.

Area of Science:

  • Pediatric Neurology
  • Nephrology and Urology
  • Hematology

Background:

  • Therapeutic plasma exchange (TPE) has evolved from manual whole blood exchange for hepatic coma.
  • Its application has broadened significantly in treating pediatric neurological conditions.
  • This expansion is driven by technological advancements and recognized clinical utility.

Purpose of the Study:

  • To provide a historical perspective on therapeutic apheresis in pediatric patients.
  • To review the current applications of TPE in managing neurological disorders in children.
  • To highlight the growing importance of TPE in pediatric neurology.

Main Methods:

  • Literature review of historical and current uses of therapeutic apheresis.
  • Focus on TPE techniques and apheresis instruments suitable for pediatric use.
  • Analysis of common neurological indications for TPE in children.

Main Results:

  • TPE is increasingly utilized in pediatric neurology.
  • Improved apheresis technology facilitates TPE in small children.
  • Numerous neurological diseases in children are now treated with TPE.

Conclusions:

  • Therapeutic plasma exchange is a valuable treatment modality for pediatric neurological diseases.
  • The historical progression and technological improvements have enhanced TPE's role.
  • TPE is a recognized and expanding therapy for a range of childhood neurological conditions.

Keywords:
TPEneurological diseasespediatric

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