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Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future

Deniz Can Guven1, Taha K Sahin2, Omer Dizdar1

  • 1Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.

Biomarkers in Medicine
|October 16, 2020
PubMed

Insights

Immune checkpoint inhibitors offer advanced NSCLC treatment, but not all patients respond. Peripheral blood biomarkers show promise for predicting immunotherapy effectiveness due to their accessibility and cost-effectiveness.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Immune checkpoint inhibitors (ICIs) have transformed advanced non-small cell lung cancer (NSCLC) treatment.
  • However, patient response to immunotherapy varies, and toxicities are a concern.
  • Current biomarkers like PD-L1 expression and tumor mutational burden have limitations.

Purpose of the Study:

  • To review recent advancements in biomarkers for predicting immunotherapy efficacy in NSCLC.
  • To highlight the potential of peripheral blood-based biomarkers.

Main Methods:

  • Literature review of recent developments in immunotherapy biomarkers for NSCLC.
  • Focus on peripheral blood-based biomarkers and their advantages.

Main Results:

  • PD-L1 expression and tumor mutational burden are established but limited biomarkers.
  • Peripheral blood biomarkers are emerging as promising, accessible, repeatable, and cost-effective predictors of immunotherapy response.
  • Various candidate biomarkers are under investigation.

Conclusions:

  • Peripheral blood biomarkers offer a promising avenue for predicting immunotherapy efficacy in NSCLC.
  • Further research into these biomarkers is warranted to overcome current treatment limitations.
Keywords:
PD-L1biomarkersimmunotherapyliquid biopsynon-small-cell lung cancertumor mutational burden

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