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Primary Ciliary Body Marginal Zone Lymphoma Presenting as Hemorrhagic Hypopyon
İrem Koç1, Hayyam Kiratli1, Yasemin Kapucu1
1Department of Ophthalmology, Ocular Oncology Service, Ankara, Turkey.
Ocular Immunology and Inflammation
|October 16, 2020
Summary
Primary ciliary body lymphoma, a rare cause of persistent anterior uveitis, was diagnosed in a patient presenting with hemorrhagic hypopyon. Early diagnosis and biopsy are crucial for effective treatment of this extranodal marginal zone lymphoma.
Area of Science:
- Ophthalmology
- Oncology
- Hematology
Background:
- Extranodal marginal zone lymphoma (EMZL) can rarely involve the ciliary body.
- Ciliary body lymphoma may present as refractory anterior uveitis.
Observation:
- A 59-year-old man presented with unilateral anterior uveitis and hemorrhagic hypopyon unresponsive to treatment.
- Anterior segment ultrasound biomicroscopy identified an iridociliary mass.
- Diagnostic cyclectomy revealed neoplastic cells positive for CD20, lambda light chain, and BCL 2.
Findings:
- Histopathological evaluation confirmed extranodal marginal zone lymphoma of the ciliary body.
- Immunohistochemistry excluded other lymphoid malignancies based on specific marker negativity.
Implications:
- Ciliary body lymphoma should be considered in cases of intractable anterior uveitis.
- Repeat biopsies may be necessary for definitive diagnosis when clinical suspicion is high.
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