Related Experiment Video

Updated: Dec 5, 2025

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

2.2K

Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic

Rabeea Siddique1,2, Qian Bai1,2, Muhammad Adnan Shereen3

  • 1Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.

Human Vaccines & Immunotherapeutics
|October 16, 2020
PubMed

Insights

This review covers Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and COVID-19, detailing its characteristics, virology, and health impacts. It emphasizes the need for evaluating unapproved vaccines and therapeutics.

Area of Science:

  • Virology
  • Public Health
  • Infectious Diseases

Background:

  • A novel coronavirus, SARS-CoV-2, emerged in late 2019, causing a global pandemic (COVID-19).
  • Uncertainties remain regarding transmission, animal origins, and effective antiviral treatments.
  • There is an urgent need for protocols to assess side effects of novel vaccines and therapeutics.

Purpose of the Study:

  • To review key characteristics and recent findings on COVID-19.
  • To explore the molecular virology and interspecies transmission mechanisms of SARS-CoV-2.
  • To discuss the health consequences associated with COVID-19.

Main Methods:

  • Literature review of recent findings on COVID-19.
  • Analysis of molecular virology and transmission pathways.
  • Examination of reported health outcomes and consequences.

Main Results:

  • Highlights salient features of COVID-19 disease.
  • Discusses molecular aspects of SARS-CoV-2 and its interspecies transmission.
  • Summarizes the health consequences of the pandemic.

Conclusions:

  • COVID-19 presents significant public health challenges requiring further research.
  • Understanding SARS-CoV-2 virology and transmission is crucial.
  • Accelerating clinical application of drugs necessitates rigorous evaluation protocols.
Keywords:
SARS-CoV-2covid-19genomehuman healththerapeutic optionsvaccine development

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.1K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.6K

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
744
Vaccinations01:51

Vaccinations

Overview
50.2K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
837
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.6K
Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
24.7K
The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
46.9K