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COVID-19 pandemic: challenges ahead.

Horacio Márquez-González1, María G Miranda-Novales2, Fortino Solórzano-Santos3

  • 1Departamento de Investigación Clínica, Hospital Infantil de México Federico Gómez. Mexico City, Mexico.

Boletin Medico Del Hospital Infantil De Mexico
|October 16, 2020
PubMed
Summary
This summary is machine-generated.

This review examines the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, focusing on its global spread, risk factors, and the lack of effective treatments. It analyzes epidemiological differences, pediatric cases, and controversial therapeutic approaches like antimalarials and steroids.

Keywords:
Angiotensin-converting enzyme-2AzithromycinAzitromicinaCOVID-19Coronavirus 2019 diseaseEnzima convertidora de angiotensina-2EsteroidesHidroxicloroquinaHydroxychloroquineSARS-CoV-2Severe acute respiratory syndrome coronavirus 2Steroids

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Area of Science:

  • * Infectious Diseases and Epidemiology
  • * Global Health Crises
  • * Virology and Public Health

Background:

  • * The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 has led to a global health crisis.
  • * SARS-CoV-2 exhibits high transmissibility and mortality, particularly in individuals over 60 and those with pre-existing conditions like obesity, diabetes, and hypertension.
  • * Currently, no specific, safe, and effective antiviral treatment exists for SARS-CoV-2 infection.

Purpose of the Study:

  • * To analyze the epidemiological variations of SARS-CoV-2 disease globally.
  • * To investigate the clinical presentation of SARS-CoV-2 in pediatric populations.
  • * To critically evaluate current treatment strategies, including empirical antimalarial and antimicrobial combinations, intravenous steroids, and the potential impact of antihypertensive medications.

Main Methods:

  • * Comprehensive literature review and analysis of published data on SARS-CoV-2 epidemiology and clinical characteristics.
  • * Critical appraisal of therapeutic interventions and their evidence base.
  • * Examination of disease presentation in diverse patient groups, including children.

Main Results:

  • * Significant global disparities in SARS-CoV-2 epidemiological patterns and risk factor prevalence were observed.
  • * The efficacy and safety of empirical treatments, such as antimalarials and steroids, remain questionable and lack robust scientific support.
  • * The potential influence of common antihypertensive drugs on SARS-CoV-2 disease progression requires further investigation.

Conclusions:

  • * The review highlights the need for evidence-based treatment guidelines for SARS-CoV-2, cautioning against unproven therapies.
  • * Further research is essential to understand the nuances of SARS-CoV-2 in different populations, especially children.
  • * Investigating the role of comorbidities and associated medications in disease outcomes is crucial for effective pandemic management.