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Spatially Fractionated Radiotherapy (GRID) Prior to Standard Neoadjuvant Conventionally Fractionated Radiotherapy for

James W Snider1, Jason Molitoris2, Susan Shyu2

  • 1University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.

Radiation Research
|October 16, 2020
PubMed
Summary

Spatially fractionated radiotherapy (GRID) shows promise for treating large tumors. A single GRID fraction before standard treatment led to excellent pathologic responses and safety in 26 patients with soft tissue sarcomas and osteosarcomas.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Spatially fractionated radiotherapy (GRID) is used for bulky tumors.
  • Modern GRID employs megavoltage photon therapy.
  • GRID offers potential for dose escalation and immunogenic effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of incorporating a single GRID fraction before standard radiotherapy for large, high-risk soft tissue and osteosarcomas.

Main Methods:

  • A single fraction of GRID radiation was administered prior to a standard fractionated course.
  • The regimen was applied to 26 consecutive patients with large (>8 cm) soft tissue and osteosarcomas.
  • Pathologic responses and safety were assessed.

Main Results:

  • Excellent pathologic responses were observed.
  • The regimen demonstrated apparent safety in the patient cohort.

Conclusions:

  • Incorporating a single fraction of GRID radiation prior to conventional therapy is a promising approach for large, high-risk soft tissue and osteosarcomas.
  • This strategy appears safe and effective, warranting further investigation.