Related Experiment Video

Updated: Dec 5, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.7K

Nrf-2 as a therapeutic target in acute kidney injury

Seyyedeh Mina Hejazian1, Seyed Mahdi Hosseiniyan Khatibi2, Abolfazl Barzegari3

  • 1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Life Sciences
|October 16, 2020
PubMed

Insights

Nuclear factor E2-related factor (Nrf-2) plays a key role in cellular protection and combating kidney diseases. Targeting Nrf-2 may offer protective effects against acute kidney injury by reducing oxidative damage.

Area of Science:

  • Cellular Biology
  • Molecular Medicine
  • Nephrology

Background:

  • Cellular homeostasis is maintained by multifaceted pathways, including the Nuclear factor E2-related factor (Nrf-2) signaling cascade.
  • Nrf-2 regulates genes involved in detoxification, antioxidant defense, anti-inflammation, and xenobiotic transport.
  • Dysregulation of these pathways contributes to various diseases, including kidney conditions.

Purpose of the Study:

  • To review the protective role of Nrf-2 in the context of kidney diseases, particularly acute kidney injury (AKI).
  • To elucidate the molecular mechanisms by which Nrf-2 influences renal adaptation and malfunction.
  • To provide evidence for Nrf-2 targeting as a therapeutic strategy against AKI.

Main Methods:

  • Literature review focusing on studies investigating Nrf-2 in kidney pathophysiology.
  • Analysis of molecular mechanisms underlying Nrf-2-mediated protection in renal injury models.
  • Synthesis of evidence regarding the impact of Nrf-2 modulation on oxidative stress and inflammation in AKI.

Main Results:

  • Nrf-2 demonstrates a dynamic and protective role in mitigating kidney injury induced by inflammation and oxidative stress.
  • Evidence suggests that activating Nrf-2 can counteract the detrimental effects of AKI.
  • Understanding Nrf-2's role is crucial for balancing renal adaptation and preventing disease progression.

Conclusions:

  • Targeting Nrf-2 presents a promising therapeutic avenue for managing acute kidney injury.
  • Modulating Nrf-2 can help ameliorate oxidative damage and its sequelae in kidney diseases.
  • Further research into Nrf-2 pathways may lead to novel treatments for renal conditions.
Keywords:
AKIKeap1-Nrf-2 systemMitochondrial dysfunctionOxidative stressRenal injury

More Related Videos

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.1K
Intravascular Delivery of Biologics to the Rat Kidney07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

8.0K

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
619
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
176
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
351
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
170
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
240
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
539