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Related Concept Videos

Hydration of Cement01:24

Hydration of Cement

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Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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Calcium phosphate cements: Optimization toward biodegradability.

I Lodoso-Torrecilla1, J J J P van den Beucken2, J A Jansen2

  • 1Dept. of Dentistry - Biomaterials, Radboudumc, Nijmegen, The Netherlands; Biomaterials, Biomechanics and Tissue Engineering Group, Department Materials Science and Metallurgy, Technical University of Catalonia (UPC), Escola d'Enginyeria Barcelona Est (EEBE), Barcelona, Spain.

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|October 16, 2020
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Summary
This summary is machine-generated.

Synthetic calcium phosphate (CaP) ceramics are vital for bone regeneration. Introducing macroporosity into injectable CaP cements (CPCs) enhances their degradation, promoting faster new bone formation for improved bone defect treatments.

Keywords:
Calcium phosphate cementsdegradationmacroporosity

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Synthetic calcium phosphate (CaP) ceramics are widely used bone regenerative biomaterials due to their bioactivity and osteoconductivity.
  • Injectable CaP cements (CPCs) offer clinical advantages for minimally invasive surgery and defect filling, but suffer from poor degradability.
  • Ideal CPCs should degrade concurrently with new bone formation, necessitating strategies to control degradation rates.

Purpose of the Study:

  • To provide a comprehensive overview of developing degradable CaP cements (CPCs).
  • To emphasize the influence of macroporosity on CPC degradation and biological performance.
  • To review experimental procedures, material properties, and pre-clinical outcomes of macroporous CPCs.

Main Methods:

  • Exploration of strategies to introduce macroporosity into CPCs to enhance degradation.
  • Characterization of (bio)material properties of macroporous CPCs.
  • Evaluation of biological performance in pre-clinical bone defect models.

Main Results:

  • Macroporosity significantly increases the surface area of CPCs, accelerating their interaction with biological environments.
  • Enhanced degradation of macroporous CPCs leads to accelerated new bone formation.
  • Pre-clinical models demonstrate improved bone regeneration with degradable CPCs.

Conclusions:

  • Controlling CPC degradation through macroporosity is a viable strategy for enhancing bone regeneration.
  • Macroporous CPCs offer improved performance over conventional CPCs in bone defect repair.
  • Further development of degradable CPCs holds significant promise for orthopedic applications.