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Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus
Tarek Sawas1,2, Saam Dilmaghani3, Lovekirat Dhaliwal1
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Introduction:
It is assumed that screening risk factors for Barrett's esophagus (BE) and prevalent esophageal adenocarcinoma (EAC) are the same.
Methods:
A matched case-control study comparing risk factors between EAC and BE was performed.
Results:
In 1,356 patients (678 with EAC and 678 with BE), heartburn (52.7%), diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome were less common in EAC (52.7, 29.2, 45.7, 48.2, 12, and 28.5%, resp.) compared with BE (84.5, 37.6, 82.2, 64.6, 18.4, and 44.1%, P < 0.01). Mean alanine aminotransferase and HgA1c levels were also significantly lower in EAC compared with BE.
Discussion:
Optimal strategies for screening for prevalent EAC may be different than that for BE.
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