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Abstract:
The concept of rhythm can be introduced in the mathematic models describing pharmacological phenomena. The modelling can take into account periodic fluctuations in the pharmacokinetic parameters (chronopharmacokinetics), or periodic fluctuations in the susceptibility of an organism to a drug (chronesthesy). It allows to choose the theoretical cases when chronotherapy could be particularly usefull, and also to propose protocols of administration taking into account the time (injection clock-time for example), in the same way that drug amount and route of administration. Modelisation also shows up the complex relationship between a temporally structured organism and an exogenous substance which has not been designed to be integrated into a set of biological rhythms.