Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Modeling in chronopharmacology].

B Hecquet

    Pathologie-Biologie
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Mathematical models can incorporate biological rhythms to optimize drug administration. This chronopharmacology approach considers timing for enhanced therapeutic effectiveness and drug delivery protocols.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Photodynamic therapy for early oesophageal cancer.

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2005
    Same author

    [Status of low-vision rehabilitation for age-related macular degeneration by orthoptists in the North of France].

    Journal francais d'ophtalmologie·2003
    Same author

    Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP). Updated results of a randomized study. Groupe Français des Myélodysplasies (GFM) and Groupe GOELAMS.

    Advances in experimental medicine and biology·1999
    Same author

    Non-invasive estimation of the circadian rhythm in serum cortisol in patients with ovarian or colorectal cancer.

    International journal of cancer·1998
    Same author

    [Information for patients with cancer of the colon: results of a survey of gastroenterologists, surgeons, and oncologists of the North region].

    Bulletin du cancer·1998
    Same author

    Quinine improves the results of intensive chemotherapy in myelodysplastic syndromes expressing P glycoprotein: results of a randomized study.

    British journal of haematology·1998
    Same journal

    Pathologie-biologie·2020
    Same journal

    Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

    Pathologie-biologie·2015
    Same journal

    [Not Available].

    Pathologie-biologie·2015
    Same journal

    Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

    Pathologie-biologie·2015
    Same journal

    Biological diagnosis of diabetes mellitus.

    Pathologie-biologie·2015
    Same journal

    Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

    Pathologie-biologie·2015
    See all related articles

    Area of Science:

    • Pharmacology
    • Mathematical Modeling
    • Chronobiology

    Context:

    • Biological systems exhibit inherent rhythms influencing drug responses.
    • Pharmacokinetic parameters and organism susceptibility can fluctuate periodically.
    • Understanding these rhythms is crucial for effective drug delivery.

    Purpose:

    • To introduce mathematical modeling of biological rhythms in pharmacology.
    • To explore chronopharmacokinetics and chronesthesy in drug action.
    • To determine optimal timing for drug administration (chronotherapy).

    Summary:

    • Mathematical models can integrate periodic fluctuations in pharmacokinetic parameters (chronopharmacokinetics) and drug susceptibility (chronesthesy).
    • This modeling approach identifies conditions where chronotherapy is most beneficial.

    Related Experiment Videos

  • It aids in designing administration protocols considering clock-time, drug dosage, and route.

    • Impact:

    • Highlights the complex interplay between biological rhythms and exogenous substances.
    • Provides a theoretical framework for optimizing drug efficacy through timing.
    • Facilitates the development of time-dependent drug administration strategies.