[Chronotherapy and allergic diseases]

The author presents a study synthesizing chronobiological data on allergic diseases and their treatment. It is referred to circannual and circadian chronobiological progress in the field of neurovegetative and immunological respiratory functions. Optimization of treatment is described for inhaled medication, adrenergic and anticholinergic bronchodilators, anti-inflammatory corticoids and cromoglycate derivatives. Importance of ingestion of corticoids at the beginning of activity and of long acting theophylline when diurnal activity ceases is described at endocrinian and pharmacodynamic level. It is finally followed by a presentation of optimization of rhinitis treatment with non sedative antihistaminics, mequitazine, terfenadine, which when taken in the evening are more efficient and better tolerated.