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[Chronobiology and renal physiopathology]
Pathologie-Biologie
|June 1, 1987
Summary
This review explores renal chronobiology, detailing how kidney functions and responses to drugs or toxins vary over time. Understanding these biological rhythms is key to optimizing treatments and minimizing side effects.
Area of Science:
- Renal physiology and chronobiology
- Pharmacology and toxicology
- Circadian and circannual rhythms
Context:
- Kidney structures and functions exhibit significant temporal variations.
- These variations are influenced by both endogenous and exogenous factors.
- Understanding these rhythms is crucial for interpreting time-dependent effects.
Purpose:
- To review recent knowledge in renal chronobiology.
- To discuss chronophysiology, chronopharmacology, and chrononephrotoxicity.
- To introduce and discuss the concept of renal chronesthesy.
Summary:
- The review covers renal chronophysiology, highlighting urinary excretion rhythms and temporal variations in kidney function.
- It examines circadian and circannual variations, explaining time-dependent effects of pathogenic, toxic, and medicinal agents.
- Recent data in chrononephrology, chronopharmacology, and chrononephrotoxicity are presented, along with the concept of renal chronesthesy.
Impact:
- Provides insights into why agents have time-dependent effects on the kidneys.
- Enhances understanding of renal target susceptibility to various substances.
- Informs the development of chronotherapeutics and chronotoxicology for improved patient outcomes.