Le transport intracellulaire des herpèsvirus

Intracellular trafficking of viruses is a vital part of the viral life cycle because of the density of the cytosol and of important distances between organelles necessary for viral replication. Viral transport is active, regulated and requires the host machinery. Transport issues are particularly important for neurotropic alpha-herpesviruses whose large capsids travel through large distances in highly specialized cells such as neurons or epithelial cells. In this review, I will summarize the knowledge accumulated for the last 15 years on the intracellular trafficking of these viruses. In this fairly recent field of research, they are among the best described because they are easily genetically modified and also because they recruit the cellular transport machinery very efficiently.