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mTOR Signaling in Metabolism and Cancer

Shile Huang1,2

  • 1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.

Cells
|October 17, 2020
PubMed

Insights

The mechanistic/mammalian target of rapamycin (mTOR) pathway regulates physiological functions and is implicated in diseases like cancer and diabetes. Targeting mTOR shows promise for treating various human disorders.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Signaling
  • Physiology

Background:

  • The mechanistic/mammalian target of rapamycin (mTOR) is a key kinase regulating cellular processes.
  • Aberrant mTOR signaling is linked to numerous pathologies, including cancer, metabolic disorders, and neurodegeneration.

Discussion:

  • This special issue reviews mTOR's role in tissue regeneration and immune function, specifically regulatory T cell differentiation.
  • It covers mTOR's involvement in diverse cancers: hematologic, skin, prostate, breast, and head and neck.

Key Insights:

  • mTOR pathway dysregulation contributes to a spectrum of human diseases.
  • The reviewed research consolidates current knowledge on mTOR signaling.

Outlook:

  • Targeting the mTOR pathway presents a viable therapeutic strategy for various human diseases.
  • Further research into mTOR signaling could unlock new treatment avenues.
Keywords:
AktPI3KmTORphotodynamic therapyregulatory T cellstissue regenerationtumor

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