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Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects

Marina Galicia-Moreno1, Silvia Lucano-Landeros1, Hugo Christian Monroy-Ramirez1

  • 1Instituto de Biologia Molecular en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.

Antioxidants (Basel, Switzerland)
|October 17, 2020
PubMed

Insights

The Nuclear factor erythroid 2-related factor (Nrf2) pathway is crucial for combating oxidative stress in liver diseases. Targeting this pathway offers a promising therapeutic strategy for various liver conditions.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Pharmacology

Background:

  • Liver diseases cause 2 million deaths annually, with oxidative stress as a key factor.
  • The Nuclear factor erythroid 2-related factor (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) pathway is a critical defense against oxidative damage.
  • This pathway is increasingly recognized as a significant therapeutic target for liver disease treatment.

Purpose of the Study:

  • To review the role of the Nrf2 pathway in major liver diseases.
  • To elaborate on the molecular mechanisms of Nrf2 signaling and its regulation by Keap1.
  • To discuss antioxidant drugs and epigenetic modifications influencing the Keap1/Nrf2 pathway.

Main Methods:

  • Comprehensive literature review of Nrf2 signaling in liver diseases.
  • Analysis of molecular and cellular mechanisms.
  • Examination of therapeutic interventions targeting the Keap1/Nrf2 pathway.

Main Results:

  • Nrf2 plays a significant role in alcoholic liver damage, viral hepatitis, steatosis, steatohepatitis, cholestatic damage, and liver cancer.
  • Modulation of the Keap1/Nrf2 pathway demonstrates potential for positive therapeutic effects.
  • Epigenetic modifications are emerging as key regulators of Keap1/Nrf2 signaling.

Conclusions:

  • The Keap1/Nrf2 pathway is a vital component of cellular defense against oxidative stress in the liver.
  • Targeting the Keap1/Nrf2 pathway presents a promising therapeutic avenue for managing diverse liver diseases.
  • Further research into epigenetic regulation of this pathway may unlock novel treatment strategies.
Keywords:
Nrf2antioxidantsepigeneticsliver damage

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