Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.3K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.7K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.7K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

167
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
167
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

910
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
910
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

1.1K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.1K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

143
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
143

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing Glycosaminoglycan-Protein Interactions: Applications of Surface Plasmon Resonance.

Biosensors·2026
Same author

Genome-environment associations reveal adaptive responses and forecast genomic offset in Calotropis procera.

Annals of botany·2026
Same author

Production and inhibition of human Heparan 6-O-Endosulfatase SULF1.

Glycobiology·2025
Same author

Genome-wide association study bridging genomics-phenomics gap in natural plant populations.

Journal of applied genetics·2025
Same author

Correction: Genome-wide association studies unveil candidate genes linked with fruit fiber traits in Calotropis procera.

Planta·2025
Same author

Genome-wide association studies unveil candidate genes linked with fruit fiber traits in Calotropis procera.

Planta·2025
Same journal

Correction: Assalve et al. Marine Algal Metabolites as Cellular Antioxidants: A Study of Caulerpin and Caulerpinic Acid in <i>Saccharomyces cerevisiae</i>. <i>Mar. Drugs</i> 2025, <i>23</i>, 338.

Marine drugs·2026
Same journal

Laurinterol, the Main <i>Smart Secondary Metabolite</i> Among Lauranes and Cyclolauranes.

Marine drugs·2026
Same journal

Red Light Enhances Biomass and Bioactive Compounds Through Photosynthetic Acclimation in <i>Anabaena variabilis</i>.

Marine drugs·2026
Same journal

Seaweed-Derived Extract Targets Porphyr'ageing to Modulate the Visible Signs of Aging in Human Skin.

Marine drugs·2026
Same journal

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

Marine drugs·2026
Same journal

Amylimycins A-C, New Bacillomycin D Analogs from Marine-Derived <i>Bacillus amyloliquefaciens</i>.

Marine drugs·2026
See all related articles

Related Experiment Video

Updated: Dec 5, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.2K

Marine Antithrombotics.

Rohini Dwivedi1, Vitor H Pomin1

  • 1Department of BioMolecular Sciences, Pharmacognosy Division, Research Institute of Pharmaceutical Sciences School of Pharmacy, University of Mississippi, Oxford, MS 38677-1848, USA.

Marine Drugs
|October 17, 2020
PubMed
Summary
This summary is machine-generated.

Marine molecules, especially sulfated polysaccharides, show promise as novel antithrombotics. These compounds offer potential therapeutic alternatives to current treatments with fewer bleeding risks, though further clinical studies are needed.

Keywords:
alkaloidsanticoagulationantithrombosisfucosylated chondroitin sulfatepolyphenolssulfated polysaccharidesterpenoids

More Related Videos

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
07:26

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

18.3K
Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.0K

Related Experiment Videos

Last Updated: Dec 5, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.2K
Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
07:26

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

18.3K
Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.0K

Area of Science:

  • Marine biotechnology
  • Pharmacology
  • Biochemistry

Background:

  • Thrombosis is a leading global cause of mortality.
  • Current antithrombotic drugs are associated with significant bleeding risks.
  • There is a need for safer and effective antithrombotic therapies.

Purpose of the Study:

  • To review the potential of marine molecules as antithrombotic agents.
  • To discuss the structural and biomedical properties of marine compounds with anticoagulant activity.
  • To highlight marine sulfated polysaccharides as promising therapeutic candidates.

Main Methods:

  • Literature review of existing research on marine antithrombotics.
  • Analysis of biochemical pathways involved in thrombosis.
  • Examination of structural and biomedical data of marine molecules.

Main Results:

  • Marine molecules, particularly sulfated polysaccharides, exhibit significant antithrombotic and anticoagulant properties.
  • These compounds possess unique mechanisms of action that may reduce bleeding complications.
  • Both low and high molecular weight marine compounds show therapeutic potential.

Conclusions:

  • Marine-derived antithrombotics represent a promising alternative to conventional treatments.
  • Further clinical investigations are essential to validate their efficacy and safety.
  • Marine molecules offer a potential solution to the limitations of current antithrombotic therapies.