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Published on: January 19, 2016
Importance of Fluorine in Benzazole Compounds
Thuraya Al-Harthy1, Wajdi Zoghaib2, Raid Abdel-Jalil2
1Department of Basic Sciences, College of Applied and Health Sciences, A'Sharqiyah University, Ibra 400, Oman.
Abstract:
Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.
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