Related Experiment Video
Updated: Dec 5, 2025
04:43
Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research
Published on: June 16, 2023
1.3K
Targeting the Choroid Plexuses for Protein Drug Delivery
Mark A Bryniarski1, Tianjing Ren1, Abbas R Rizvi1
1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo: 304 Pharmacy Building, Buffalo, NY 14214, USA.
Pharmaceutics
|October 17, 2020
Summary
Targeting the choroid plexus offers a new strategy for delivering protein therapeutics to the central nervous system, bypassing the blood-brain barrier. This approach may unlock novel treatments for brain diseases.
Area of Science:
- Neuroscience
- Pharmacology
- Biomedical Engineering
Background:
- Central nervous system drug delivery faces significant challenges due to protective brain barriers.
- Protein therapeutics are particularly difficult to deliver across these barriers, including the blood-brain barrier.
- The choroid plexus acts as a critical interface between the systemic circulation and the brain's ventricular system.
Purpose of the Study:
- To review the role of the choroid plexus and ventricular system in central nervous system drug delivery.
- To explore the potential of targeting the choroid plexus as a strategy for delivering protein therapeutics.
- To discuss methods for evaluating protein transport across the choroid plexus.
Main Methods:
- Review of preclinical methods for assessing protein transport across the choroid plexus.
- Analysis of imaging strategies, ventriculocisternal perfusions, and cell models.
- Consideration of cerebrospinal fluid dynamics in drug disposition.
Main Results:
- The choroid plexus presents a potential surrogate target to circumvent the blood-brain barrier for drug delivery.
- Receptor-mediated transcytosis is a promising mechanism for protein therapeutic delivery across choroid plexus epithelial cells.
- Cerebrospinal fluid flow and other barriers necessitate careful evaluation for effective drug disposition.
Conclusions:
- The choroid plexus and ventricular system are crucial barriers and potential delivery routes for central nervous system therapeutics.
- Targeting the ventricular system with protein therapeutics offers novel therapeutic avenues for central nervous system diseases.
- Further research into choroid plexus transport mechanisms is vital for advancing brain drug delivery.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
633
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
633
01:27Open Angle Glaucoma: Treatment
859
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
859
01:25Physiological Barriers
4.8K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
4.8K
01:29Drug Delivery: Parenteral Route
1.3K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.3K
01:17Pore Transport and Ion-Pair Transport
972
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
972
01:23Factors Affecting Drug Distribution: Physiological Barriers
552
Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
552