Related Experiment Video
Updated: Dec 5, 2025
Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
Application of autologous endometrial mesenchymal stromal/stem cells increases thin endometrium receptivity: a case
I M Sapozhak1,2, О S Gubar1,3, A E Rodnichenko1,2,4
1Biotechnology Laboratory Ilaya.Regeneration, Medical Company Ilaya, I. Kramskogo Street, 9, Kiev, 03115, Ukraine.
Background:
Pregnancy in cycles with the use of assisted reproductive technologies is possible only with the availability of good-quality embryos and a healthy receptive endometrium. The problem of lack of sensitivity of the endometrium is related to the syndrome of thin endometrium, which is caused by a number of factors. However, there is no single protocol for the treatment of this syndrome, the return/improvement of normal functionality of endometrial tissue, and obtaining the desired pregnancy.
Case Presentation:
We report a case of a 38-year-old Ukrainian woman with a number of unsuccessful tries at pregnancy in cycles with the use of assisted reproductive technologies. We describe a clinical case of the use of mesenchymal stem cells of the human endometrium for a woman with thin endometrial syndrome to increase its receptivity for pregnancy. The basic steps of patient management, protocol of sampling material for obtaining a cell product based on endometrial stem cells, their basic morphofunctional characteristics, and post-treatment procedures to obtain the desired pregnancy are described.
Conclusion:
Application of autologous endometrial mesenchymal stem cells increases endometrial receptivity and the chance for pregnancy with use of assisted reproductive technologies.
