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Updated: Dec 5, 2025
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Published on: July 28, 2010
P-Gp and TOPO II Expression and Their Clinical Significance in Colon Cancer
Yuan Dang1, Fangfang Liu2, Yiju Zhao3,4
1Laboratory of Basic Medicine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
Objective:
Analysis of P-Gp and TOPO II expression levels and their clinical significance in colon cancer.
Methods:
A total of 300 cases of paraffin embedded specimens of primary colon cancer were collected from the Affiliated Hospital of Putian University. The levels of P-Gp and TOPO II expression in colon cancer tissues were detected by the two-step En Vison.
Results:
P-glycoprotein (P-Gp) was mainly localized in the membrane and nucleus of colon cancer cells and the positive expression rate was 62% (186/300). The positive expression of P-Gp correlated with gender, invasion depth and lymph node metastasis and the differences were statistically significant (P<0.05). Topoisomerase II (TOPO II) was mainly expressed in the cell nucleus and the positive rate was 83.3%. A total of 250 out of 300 samples were TOPO II positive and exhibited significant correlation with invasion depth, lymph node metastasis and differentiation degree (P<0.05). Spearman correlation analysis indicated that P-Gp and TOPO II expression levels in colon cancer were positively correlated (r=0.480).
Conclusion:
P-Gp and TOPO II expression levels were associated with colon cancer progression.
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