Cohort protocol: Guangzhou High-Risk Infant Cohort study

Area of Science:

• Pediatrics
• Neurodevelopmental Disorders
• Public Health

Background:

• High-risk infants (HRIs) show increasing survival rates globally.
• However, motor and neurodevelopmental sequelae prevalence remains high in HRIs.
• Limited research exists on HRIs in China, highlighting a knowledge gap.

Purpose of the Study:

• To establish the Guangzhou High-Risk Infant Cohort (GHRIC) in China.
• To examine factors influencing the growth and neurodevelopment of HRIs.
• To identify risk factors and prognoses for improved infant development.

Main Methods:

• Prospective cohort study enrolling 3000 HRIs by 2023.
• Data collection includes risk factors, neurodevelopmental/cognitive evaluations, lab results, and specimens.
• Follow-up until age 6 to record interventions and outcomes.

Main Results:

• Data collection and analysis are ongoing.
• The study aims to identify key developmental trajectories and influencing factors.
• Results will inform targeted interventions for HRIs.

Conclusions:

• The GHRIC study is crucial for understanding HRI development in China.
• Findings will contribute to improved neurodevelopmental outcomes for high-risk infants.
• This research will inform clinical practice and public health strategies.