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Cohort protocol: Guangzhou High-Risk Infant Cohort study
1Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Insights
The Guangzhou High-Risk Infant Cohort (GHRIC) investigates factors affecting high-risk infants (HRIs) in China. This study aims to improve neurodevelopmental outcomes for these vulnerable newborns.
Area of Science:
- Pediatrics
- Neurodevelopmental Disorders
- Public Health
Background:
- High-risk infants (HRIs) show increasing survival rates globally.
- However, motor and neurodevelopmental sequelae prevalence remains high in HRIs.
- Limited research exists on HRIs in China, highlighting a knowledge gap.
Purpose of the Study:
- To establish the Guangzhou High-Risk Infant Cohort (GHRIC) in China.
- To examine factors influencing the growth and neurodevelopment of HRIs.
- To identify risk factors and prognoses for improved infant development.
Main Methods:
- Prospective cohort study enrolling 3000 HRIs by 2023.
- Data collection includes risk factors, neurodevelopmental/cognitive evaluations, lab results, and specimens.
- Follow-up until age 6 to record interventions and outcomes.
Main Results:
- Data collection and analysis are ongoing.
- The study aims to identify key developmental trajectories and influencing factors.
- Results will inform targeted interventions for HRIs.
Conclusions:
- The GHRIC study is crucial for understanding HRI development in China.
- Findings will contribute to improved neurodevelopmental outcomes for high-risk infants.
- This research will inform clinical practice and public health strategies.
Introduction:
Despite the increase in the survival rate of high-risk infants (HRIs) worldwide, the prevalence of motor and neurodevelopmental sequelae in such newborns has not shown concomitant improvement. Meanwhile, there are few cohorts that explore factors related to the development of HRIs in China. Therefore, the Guangzhou High-Risk Infant Cohort (GHRIC) has been designed to examine the complex relationships among a myriad of factors influencing growth and development in such children.
Methods And Analysis:
The GHRIC study is a prospective cohort study that by the year 2023 will enrol an estimated total of 3000 HRIs from Guangzhou Women and Children's Medical Center (GWCMC) in Guangzhou, China. This study is designed to assess the growth and cognitive characteristics of HRIs and the risk factors affecting their development and prognoses. Data on risk factors, neurodevelopmental and cognitive-function evaluations, laboratory results, and specimens will be collected and analysed. Information on perinatal and clinical interventions for these infants will also be recorded during regular follow-up visits until age 6.
Ethics And Dissemination:
The protocol for this study has been approved by the Research Ethics Committee of GWCMC, which accepted responsibility for supervising all of the aspects of the study (No. 2017102712). Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the Internet and social media.
Trial Registration Number:
ChiCTR-EOC-17013236.
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