Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Mitral Regurgitation I: Introduction

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

Aortic Regurgitation III: Medical Management

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aldosterone-targeted Therapy after Primary Aldosteronism Testing in Resistant Hypertension: A Nationwide Cohort Study.

medRxiv : the preprint server for health sciences·2026

Same author

NT-proBNP and its association with autonomous aldosterone production in primary aldosteronism.

Therapeutic advances in endocrinology and metabolism·2026

Same author

Consensus on the management of hypertension in individuals with diabetes by Asian-Pacific Society of hypertension (APSH) & Diabetes Asia Study Group (DASG).

Journal of human hypertension·2026

Same author

Sacubitril/valsartan for the prevention of cancer therapy-related cardiac dysfunction: a systematic review and meta-analysis.

Cardio-oncology (London, England)·2026

Same author

Dysregulated Aldosterone Production in Obesity Is Associated With Adverse Cardiac Structure, Function, and Adiposity.

Circulation·2026

Same author

Sex Differences in Cardiac Remodeling and Dysfunction in Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)·2026

Same journal

Previous COVID-19 infection: An overlooked cardiovascular risk factor.

Journal of human hypertension·2026

Same journal

Patient out-of-pocket costs for antihypertensive single pill combination products with cost caps.

Journal of human hypertension·2026

Same journal

Mindfulness based interventions for blood pressure reduction: systematic and umbrella review of existing meta-analyses.

Journal of human hypertension·2026

Same journal

Invasive observation of reactive systolic blood pressure responses to upper-arm cuff inflation.

Journal of human hypertension·2026

Same journal

Association between post-thrombectomy blood pressure trajectories and clinical outcomes in hypertensive patients with acute ischemic stroke: a retrospective cohort study.

Journal of human hypertension·2026

Same journal

Systemic inflammation indices generated from first-trimester blood tests can be potential biomarkers for predicting preeclampsia.

Journal of human hypertension·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 5, 2025

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Left ventricular remodeling and dysfunction in primary aldosteronism.

Cheng-Hsuan Tsai^1,2, Chien-Ting Pan^2,3, Yi-Yao Chang⁴

¹Department of Internal Medicine, National Taiwan University Hospital Jinshan Branch, New Taipei City, Taiwan.

Journal of Human Hypertension

|October 17, 2020

Summary

This summary is machine-generated.

Primary aldosteronism (PA) causes hypertension and heart problems. Treatment can improve left ventricular remodeling and dysfunction in PA patients.

More Related Videos

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

Related Experiment Videos

Last Updated: Dec 5, 2025

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

Area of Science:

Cardiology
Endocrinology
Hypertension Research

Background:

Primary aldosteronism (PA) is a frequent cause of secondary hypertension.
PA is linked to adverse cardiovascular outcomes, including left ventricular (LV) remodeling and dysfunction.

Purpose of the Study:

To review the mechanisms of aldosterone-induced LV remodeling.
To summarize clinical research on LV remodeling, cardiac dysfunction, and clinical impacts in PA patients.

Main Methods:

Review of clinical studies and research on primary aldosteronism.
Analysis of mechanisms driving aldosterone-induced cardiac changes.

Main Results:

PA leads to increased LV mass and cardiac fibrosis compared to essential hypertension.
Aldosterone promotes LV remodeling via profibrotic effects, oxidative stress, and endothelial dysfunction.
LV remodeling results in diastolic and systolic dysfunction, increasing risks for heart failure and arrhythmias.

Conclusions:

Aldosterone significantly contributes to detrimental cardiac remodeling and dysfunction in PA.
Effective treatments, including adrenalectomy and medical therapy, can reverse LV remodeling and improve cardiac function in PA patients.