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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Related Experiment Video

Updated: Dec 5, 2025

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
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Preparation and characterization of curcumin solid dispersion using HPMC.

Ji Young Yu1, Jin A Kim1, Hee Joung Joung1,2

  • 1Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Anam-dong, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Journal of Food Science
|October 17, 2020
PubMed
Summary

Hydroxypropyl methylcellulose (HPMC) solid dispersions significantly enhance curcumin

Keywords:
HPMCamorphous solid dispersioncurcuminsolubility

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Food Science

Background:

  • Curcumin exhibits poor water solubility, limiting its bioavailability and applications.
  • Developing water-soluble curcumin is crucial for enhanced therapeutic and functional food uses.
  • Solid dispersion technology offers a promising approach to improve curcumin's physicochemical properties.

Purpose of the Study:

  • To prepare curcumin solid dispersions using hydroxypropyl methylcellulose (HPMC).
  • To enhance the water solubility and dissolution of curcumin.
  • To evaluate the potential of these solid dispersions as a delivery system for food applications.

Main Methods:

  • Curcumin solid dispersions were prepared using hydroxypropyl methylcellulose (HPMC).
  • Particle size, encapsulation efficiency, and water solubility were analyzed.
  • Physicochemical characterization included X-ray diffraction, DSC, and FTIR.
  • Dissolution behavior and release kinetics were studied.

Main Results:

  • Curcumin solid dispersions exhibited particle sizes between 371-528 nm.
  • Encapsulation efficiency exceeded 93% for all formulations.
  • Water solubility of curcumin improved to 238 µg/mL at a 20:80 curcumin:HPMC ratio.
  • Transformation of crystalline curcumin to an amorphous form was confirmed.
  • Enhanced dissolution and sustained release profiles were observed.

Conclusions:

  • Curcumin solid dispersions with HPMC significantly improve curcumin's water solubility and dissolution.
  • The amorphous form of curcumin in solid dispersions enhances bioavailability.
  • These findings demonstrate the potential of HPMC-based curcumin solid dispersions as a functional ingredient in the food industry.