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[Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO]
1Department of Transfusion，The First Hospital of China Medical University，Shenyang 110001，Liaoning Province, China.
Objective:
To explore the expression of clec2 in patients with myelodysplastic syndrome (MDS) and to analyze its correlation with TPO.
Methods:
The expression of plasma clec2 in 47 patients with MDS and 20 normal controls was detected by ELISA, and the correlation between the clinical characteristics of MDS patients and clec2 expression was analyzed. Meanwhile, the expression level of plasma TPO in 42 patients with MDS was detected, and its correlation with clec2 was analyzed.
Results:
The expression of clec2 was 171.5.2±57.6 ng/ml in normal controls and 347.9±121.5 ng/ml in patients with MDS (P＜0.01). The expression level was 375.4±124.3 ng/ml in the initial treatment patients and 288.6±98.7 ng/ml in the re-treatment patients (P＜0.05). There was no relationship between clec2 and sex, age, number of peripheral blood cells, bone marrow blast cells. However, further analysis showed that there was a positive correlation between clec2 and TPO (r=0.419, P＜0.01).
Conclusion:
Clec2 is highly expresses in MDS patients and positively correlates with TPO. The interaction between clec2 and TPO may play an important role in the occurrence and development of MDS, which may be the new molecular mechanism and mechanism of targeted therapy.
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