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Neuroendocrine mechanisms and aging.

C E Finch

    Federation Proceedings
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Neuroendocrine function changes with aging, particularly in reproductive systems. While hypothalamic and ovarian changes occur, the exact cause of reproductive aging remains unclear.

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    Area of Science:

    • Neuroendocrinology
    • Reproductive Biology
    • Aging Research

    Background:

    • Aging is associated with significant alterations in neuroendocrine function.
    • Key systems affected include the brain-pituitary-ovarian-adrenal-hepatic and brain-pituitary-ovarian axes.
    • Interpreting age-related pituitary function changes presents challenges due to discordant data.

    Purpose of the Study:

    • To review evidence on neuroendocrine function alterations during aging.
    • To focus on changes within the brain-pituitary-ovarian-adrenal-hepatic and brain-pituitary-ovarian systems.
    • To discuss potential mechanisms of reproductive aging.

    Main Methods:

    • Review of existing scientific literature and evidence from multiple laboratories.
    • Analysis of data related to neuroendocrine system changes in aging.

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  • Examination of mechanisms at both ovarian and hypothalamic levels.

    • Main Results:

    • Evidence suggests changes in ovarian and hypothalamic function contribute to reproductive aging.
    • Reduced catecholamine levels, turnover, and synaptosomal uptake are implicated.
    • Dopaminergic impairments in basal ganglia are observed in aging humans and rodents, suggesting a general aging phenomenon.

    Conclusions:

    • Age-related changes in hypothalamic catecholamine metabolism are not definitively proven as the primary cause of lost reproductive cycles.
    • Dopaminergic impairments may be a general feature of aging, not solely linked to neuronal cell loss in the substantia nigra.
    • Further research is needed to fully understand the origins and implications of these neuroendocrine changes in aging.