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Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer's disease scale: development and
Ines Rombach1, Marvi Iftikhar2, Gurleen S Jhuti3
1Nuffield Department of Population Health, Health Economics Research Centre, University of Oxford, Old Road Campus, Oxford, OX3 7LF, United Kingdom. ines.rombach@ndorms.ox.ac.uk.
Purpose:
The Quality of Life Alzheimer's Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.
Methods:
Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.
Results:
The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.
Conclusions:
The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.
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