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Related Concept Videos

Obesity01:24

Obesity

992
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
992
Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

160
Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
160
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

201
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
201
Self-Evaluation Maintenance Model01:29

Self-Evaluation Maintenance Model

168
The Self-Evaluation Maintenance (SEM) model offers a psychological framework to understand how individuals’ self-esteem is influenced by the achievements of others, particularly those with whom they share close personal bonds. The SEM model operates when personal rather than social identity guides individuals. Central to this model is the notion that individuals have an inherent desire to preserve a favorable self-image, which is continuously shaped by interpersonal comparisons and...
168
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

170
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
170
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

190
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
190

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Related Experiment Video

Updated: Dec 5, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

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The clinical obesity maintenance model: a structural equation model.

Dean Spirou1, Evelyn Smith2,3, Katie Wood1

  • 1Discipline of Clinical Psychology, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.

Eating and Weight Disorders : EWD
|October 17, 2020
PubMed
Summary

This study empirically tested the Clinical Obesity Maintenance Model (COMM), finding that cognitive flexibility, eating habits, beliefs, emotion regulation, and depression significantly influence weight management. These psychological factors offer insights into obesity maintenance.

Keywords:
ObesityPsychological factorsWeight maintenanceWeight management

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Area of Science:

  • Psychology
  • Clinical Psychology
  • Obesity Research

Background:

  • Theoretical research on psychological factors in weight management is limited.
  • The Clinical Obesity Maintenance Model (COMM) proposes psychological and neuropsychological mechanisms maintaining weight issues.
  • Empirical validation of the COMM is needed to understand its components.

Purpose of the Study:

  • To empirically test the Clinical Obesity Maintenance Model (COMM).
  • To elucidate the psychological and neuropsychological underpinnings of weight management issues.
  • To evaluate the model fit and associations between hypothesized variables.

Main Methods:

  • Cross-sectional descriptive study with 165 Australian adults (normal weight, overweight, obesity).
  • Data collected via self-report questionnaires and neuropsychological testing.
  • Structural equation modelling used to analyze associations and model fit.

Main Results:

  • The COMM demonstrated acceptable to good model fit.
  • Cognitive flexibility directly influenced eating habit strength.
  • Eating habits influenced eating beliefs, which affected emotion dysregulation.
  • Emotion dysregulation was linked to depression and binge eating, with partial mediation by depression.
  • Depression directly predicted binge eating.

Conclusions:

  • This study provides the first empirical test and preliminary support for the COMM.
  • Identified psychological and neuropsychological mechanisms contributing to weight management issues.
  • Future research should refine and integrate the COMM into holistic weight management models for improved outcomes.