Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

95
Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
95
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

167
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
167
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

151
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
151
Veins01:17

Veins

8.1K
Veins are an integral part of our circulatory system, serving as the blood vessels that transport blood from all body regions to the heart. They are a network of hollow tubes that carry blood low in oxygen from the body's cells back to the heart for reoxygenation. Veins are crucial for maintaining the body's overall fluid balance and the continuous circulation of blood.
Structure of Veins:
The structure of veins is specifically designed to assist in the low-pressure transportation of...
8.1K
Veins of Lower Limbs01:15

Veins of Lower Limbs

1.9K
The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
1.9K
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

91
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
91

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influenza Vaccines for Persons Who Are Immunocompromised: A Scoping Review of the Literature.

Open forum infectious diseases·2026
Same author

Risankizumab versus Deucravacitinib in Adults With Moderate Plaque Psoriasis: 16-Week Results from the Phase 4 IMMpactful Trial.

Dermatology and therapy·2026
Same author

Trichome formation in <i>Nicotiana benthamiana</i> is induced by certain <i>Agrobacterium tumefaciens</i> strains.

Frontiers in plant science·2026
Same author

Left Ventricular Venting Strategies for Cardiogenic Shock in Patients Treated With Extracorporeal Cardiopulmonary Support V-A ECMO: From Left Ventricular Unloading to Offloading.

The American journal of cardiology·2026
Same author

Challenges in defining severe influenza with implications for measuring and communicating influenza vaccine effects.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection.

Frontiers in physiology·2026
Same journal

The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

Seminars in pediatric surgery·2026
Same journal

Appendicitis as a model for pediatric surgical quality improvement and standardization.

Seminars in pediatric surgery·2026
Same journal

From FOB to PICU: military trauma systems that changed pediatrics.

Seminars in pediatric surgery·2026
Same journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026
Same journal

Radio-surgical decision-making in hepatoblastoma in the post-PHITT era: SIOPEL consensus recommendations.

Seminars in pediatric surgery·2026
Same journal

Seminars in pediatric sugery pediatric metabolic and bariatric surgery.

Seminars in pediatric surgery·2026
See all related articles

Related Experiment Video

Updated: Dec 5, 2025

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.6K

Venous malformations.

Jo Cooke-Barber1, Sara Kreimer2, Manish Patel3

  • 1Division of General and Thoracic Pediatric Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229, United States.

Seminars in Pediatric Surgery
|October 18, 2020
PubMed
Summary
This summary is machine-generated.

New therapies, including Sirolimus targeting the mTOR/PI3K/AKT pathway and advanced sclerotherapy, show promise for improving symptoms and function in patients with common venous malformations.

More Related Videos

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

10.0K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.8K

Related Experiment Videos

Last Updated: Dec 5, 2025

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.6K
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

10.0K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.8K

Area of Science:

  • Vascular anomalies
  • Medical therapy
  • Interventional radiology

Background:

  • Venous malformations are common slow-flow vascular anomalies requiring multidisciplinary care.
  • Current management focuses on symptom amelioration and function preservation, with therapeutic compression as the primary treatment.

Purpose of the Study:

  • To review recent advances in the management of venous malformations.
  • To highlight promising new therapeutic options for improving patient outcomes.

Main Methods:

  • Review of recent literature on venous malformation therapies.
  • Discussion of novel medical and interventional approaches.

Main Results:

  • Therapeutic compression garments remain a cornerstone of venous malformation management.
  • Emerging therapies, including Sirolimus (mTOR/PI3K/AKT pathway inhibitor) and refined sclerotherapy techniques, demonstrate significant potential.

Conclusions:

  • Advances in medical therapy and sclerotherapy offer new hope for long-term symptom improvement in venous malformations.
  • These novel approaches are expected to enhance the optimal care of patients with these complex vascular anomalies.