Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.7K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.7K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.6K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.6K
Metastasis02:30

Metastasis

6.2K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.7K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.3K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cluster-guided adversarial graph contrastive learning.

Neural networks : the official journal of the International Neural Network Society·2026
Same author

Emergence of Lineage E.4 and Structural Plasticity of A28L Protein in Mpox Virus: Characterization of LCR7 Length Polymorphisms Across Lineages - Shenzhen City, Guangdong Province, China, 2023-2025.

China CDC weekly·2026
Same author

Genomic characterization of a large-scale chikungunya outbreak in China.

The Journal of infection·2026
Same author

Amniotic membrane transplantation combined with cryotherapy vs. lamellar keratoplasty for medically refractory peripheral ulcerative keratitis: a retrospective cohort study.

Frontiers in medicine·2026
Same author

Extruded biodegradable Zn-5Cu alloys with integrated osteoimmunomodulatory, antibacterial, and anti-osteolytic properties for patellar fracture suture repair.

Acta biomaterialia·2026
Same author

Control of Circularly Polarized Luminescence in Cholesteric Luminescent Liquid Crystals: From FRET to Exciton Coupling.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Dec 5, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.7K

Cellular plasticity and drug resistance in sarcoma.

Zhengjun Lin1, Zhihua Fan1, Xianghong Zhang2

  • 1Xiangya School of Medicine, Central South University, Changsha 410013, Hunan Province, China.

Life Sciences
|October 18, 2020
PubMed
Summary

This review explores cellular plasticity in sarcoma, a rare cancer with poor outcomes. Understanding plasticity mechanisms is key to overcoming chemotherapy resistance and developing new sarcoma treatments.

Keywords:
Cellular plasticityDrug resistanceEpithelial-mesenchymal transitionSarcomaTumor microenvironment

More Related Videos

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.5K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.0K

Related Experiment Videos

Last Updated: Dec 5, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.7K
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.5K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.0K

Area of Science:

  • Oncology
  • Cancer Biology
  • Cellular Plasticity

Background:

  • Sarcomas are rare malignant tumors with poor prognosis and low chemotherapy response rates.
  • Sarcoma cells frequently develop multi-drug resistance (MDR) through intrinsic or acquired resistance mechanisms.
  • Cancer cellular plasticity is increasingly recognized for its role in cancer progression, therapy resistance, and relapse.

Purpose of the Study:

  • To review the regulatory mechanisms of cellular plasticity in sarcoma.
  • To elucidate the pathological roles of cellular plasticity in sarcoma progression and chemoresistance.
  • To identify cellular plasticity as a potential therapeutic target for overcoming sarcoma drug resistance.

Main Methods:

  • Literature review of recent studies on cellular plasticity in sarcoma.
  • Analysis of molecular mechanisms regulating cancer cellular plasticity.
  • Examination of the link between cellular plasticity, sarcoma progression, and drug resistance.

Main Results:

  • Cellular plasticity is implicated in sarcoma progression and the development of chemoresistance.
  • Factors such as genetic/epigenetic alterations, tumor microenvironment, and treatment pressure regulate plasticity.
  • Understanding these mechanisms is crucial for addressing sarcoma treatment challenges.

Conclusions:

  • Cellular plasticity significantly contributes to sarcoma progression and therapeutic resistance.
  • Targeting cellular plasticity offers a promising strategy to improve sarcoma treatment outcomes.
  • Further research into plasticity regulation is essential for developing novel anti-sarcoma therapies.