Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Marchetti et al. MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles. <i>Int. J. Mol. Sci</i>. 2020, <i>21</i>, 1733.

International journal of molecular sciences·2026
Same author

Clinical effect of proprotein convertase subtilisin/kexin type 9 inhibition in patients undergoing coronary artery bypass surgery.

JTCVS open·2026
Same author

Severe hypoxia drives loss of ST6GAL1-mediated α2,6-sialylation in the epicardial secretome impairing angiogenic activity.

Biology open·2026
Same author

Exploratory observational study with Two-year outcomes of early in-hospital evolocumab in acute coronary syndrome patients undergoing coronary artery bypass grafting.

Frontiers in cardiovascular medicine·2026
Same author

Interleukin 11-Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis.

Circulation research·2026
Same author

Senescence-related myocardial dysfunction: keeping a young heart.

European heart journal·2026

Related Experiment Video

Updated: Dec 5, 2025

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.4K

Remote ischemic preconditioning in isolated valve intervention. A pooled meta-analysis.

Marco Moscarelli1, Gianni D Angelini2, Costanza Emanueli1

  • 1Imperial College London, National Heart Lung Institute, UK.

International Journal of Cardiology
|October 18, 2020
PubMed
Summary

Remote ischemic preconditioning (RIPC) may protect the heart during valvular interventions, reducing myocardial injury. However, RIPC did not improve early clinical outcomes in patients undergoing these procedures.

Keywords:
Aortic valveIschemia/reperfusion injuryRemote ischemic preconditioningTranscatheter aortic valve intervention (TAVI)

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.0K
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.2K

Related Experiment Videos

Last Updated: Dec 5, 2025

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.4K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.0K
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.2K

Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Interventional Cardiology

Background:

  • Remote ischemic preconditioning (RIPC) has shown no benefit in coronary artery bypass surgery.
  • Patients undergoing cardiac surgery may have natural preconditioning due to prior ischemia.
  • The efficacy of RIPC in valvular interventions remains under-investigated.

Purpose of the Study:

  • To investigate the role and efficacy of RIPC in patients undergoing isolated valve interventions.
  • To assess the impact of RIPC on periprocedural myocardial injury and clinical outcomes in valvular procedures.

Main Methods:

  • A systematic literature review and meta-analysis of 8 studies involving 610 patients (312 RIPC, 298 SHAM).
  • Primary outcome: periprocedural myocardial injury assessed by serum troponin levels.
  • Secondary outcomes: intra- and post-operative clinical events; subgroup analyses performed.

Main Results:

  • RIPC demonstrated a significant reduction in periprocedural troponin release (SMD: 0.74 [95% CI: 0.52; 0.95], p=0.02) with no heterogeneity.
  • No significant improvement in early post-operative clinical outcomes was observed with RIPC.
  • No serious adverse events related to RIPC were reported.

Conclusions:

  • RIPC appears to offer periprocedural cardioprotection in patients undergoing valvular interventions.
  • Despite reduced myocardial injury markers, RIPC does not translate to improved early clinical outcomes in this patient group.